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severity of male urogenital feminization (hypospadias) in the mouse model. Hypospadias is one feminization was developed, and validated against histologi-. the following urogenital and integumental tissues of embryonic mice: seminal . Histologi- cal examination demonstrated that normal morphogenesis and. Urogenital Epithelium by the Polyoma Virus. Middle T tive urogenital tissues, especially the prostate. .. within another area of the dorsal prostate histologi-.

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This section of notes gives an overview mainly of adult renal histology, see also Renal System Development notes. Moodle – Virtual Slides requires Moodle log in.

Mouse renal podocyte EM [1]. On the outside of the capillary, the foot processes FP cover a major part of the glomerular basement membrane GBM circumference. The endothelial cell coats the inner surface of the capillary wall and is followed by the three layers of the glomerular basement membrane GBM.

Note that while the smooth muscle fibre layer organisation is described as longitudinal or circular, this is only a general organisation of fibre direction, and histologj better described as a “spiral” organisation. External Links Notice – The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer histologl search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement.

UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation. Discussion View urogenitql History. Renal System Histology From Embryology. This page was last modified on 30 Augustat Privacy policy About Embryology Disclaimers.

Google Translate – select your language from the list shown below this will open a new external page. Nephron Functional unit of kidney Humans up to 1 million Filtration of waste from blood Endocrine Blood pressure regulation. Transmission electron micrscopy of a mouse glomerular capillary revealing the structural composition of the glomerulus.

The slit-diaphram can be discerned in between the foot processs. The adult ureter is a thick-walled muscular tube, 25 – 30 cm in length, running from the kidney to the urinary bladder.


Anatomically can be described in two parts the abdominal part pars abdominalis and pelvic part pars pelvina. The ureter is composed of three layers: The muscular layer has also been described as being subdivided into 3 fibre layers: Can be described anatomically by its 4 layers from inside outward: Mucosa – mucus layer a transitional epithelium layer formed into folds rugae.

Submucosa – connects the muscular layer with the mucous layer. Muscular – the detrusor muscle is the muscle of the urinary bladder wall.

Serous – the superior or abdominal surfaces and the lateral” surfaces of the bladder are covered by visceral peritoneum, the serous membrane serosa of the abdominal cavity, consisting of mesthelium and elastic fibrous connective tissue.

Detrusor Muscle The adult detrusor muscle consists of three layers of smooth involuntary muscle fibres. Capsule outer layer – dense CT fibroblasts and urogrnital inner layer – myofibroblasts. Wilm’s tumour Bowman’s capsule – capsula glomeruli, glomerular capsule Surrounds the glomerulus within the nephron with a vascular and urinary pole and is the beginning of the tubular component.

Named in after Sir William Bowman — an English surgeon and anatomist.

Renal System Histology

Brenner hypothesis – a clinical hypothesis that states, individuals with a congenital reduction in nephron number have a much urogeital likelihood of developing adult hypertension and subsequent renal failure. PubMed Barry Brenner capillary loop – C stage The third stage in nephron development between weeks. V – S – C – M diabetes insipidus – The disorder is related to the hormone antidiuretic hormone ADH, also called vasopressin its synthesis, secretion, receptors and signaling pathway.

This leads to a grossly dilated renal pelvis causing extensive renal damage before birth. Normally the majority of nephrogenic rests either regress or become dormant.

Region also in close contact with the efferent and afferent arterioles of the glomerulus and involved in sodium chloride histologk. V – S – C – M mesangial cells – Cells in the nephron glomerulus that form the connective tissue giving structural support to podocytes and vessels.

The intermediate mesonephros develops and disappears with the exception of its duct, the mesonephric ductwhich will form the male reproductive duct system. In males, the mesonephric tubules go on to form the ducts of the testis.


In females, these degenerate. A few mesonephric tubules remain as efferent ductules in the male and vestigial remnants in the female. In females this duct degenerates some remnants may remain associated in broad ligament. This is non-familial and is produced by atresia of a ureter and is always unilateral.

These neoplastic rests can develop postnatally as a benign form adenomatous rest or a malignant Wilm’s tumour form. The rests are further characterised by the time of generation leading to different anatomical kidney locations: The inner layer is the visceral layer.

Renal System Histology – Embryology

Podocytes form the visceral layer of Bowman’s capsule and are urogenitql the filtration barrier between capillary blood and the nephron tubular system and function to ultrafiltrate blood, and support glomerular capillary pressures.

The differentiation of podocytes involves the formation of cellular foot processes and then the slit membrane. This forms the kidney of primitive fish and lower vertebrates.

Kidney development occurs within the intermediate mesoderm interacting with endoderm.

In humans, this very rudimentary kidney forms very early at the level of the neck. It is rapidly replaced by the mesonephros, intermediate stage kidney, differentiating in mesoderm beneath. V hisologi S – C – M transitional epithelium – urothelium Histological term to describe the epithelium lining the ureters and urinary bladder. They develop from the ureteric bud and are lined by a transitional epithelium with an outer muscular wall. In humans, the urethral length differs between the sexes male longer, female shorter.

Cytoplasm urogdnital a fenestrated epithelium around the fenestrated capillaries of the glomerulus. The outer layer is the parietal layer. V – S – C – M urinary – Term used to describe all components of the kidney system including the bladder, ureters and urethra. Wt1 also required at early stages of gonadal development. Named after Caspar Friedrich Wolffa German scientist and early embryology researcher and is said to have established the doctrine of germ layers.