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Horizon Scanning Technology. Prioritising Summary. LifePort. ® kidney transporter: A portable donor kidney transporter/ perfuser. November 24 – What to do after pumping begins. 28 – Removing a kidney from LifePort Kidney Transporter; removing used Perfusion Circuit after a case. 34 – 45 . The LifePort Kidney Transporter is a revolutionary method of transporting kidneys for transplantation: it is a portable, insulated perfusion transporter with.

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User observations were carried out on products in similar categories to ensure its high portability, robustness, ease of use and clinical efficiency. Perfusate samples from the portal inflow and the catheter cannulated in suprahepatic vena cava were respectively collected and measured using a pH-blood gas analyzer i-STAT; Abbott Point of Care, Inc. To overcome the shortage of brain-dead donors for liver transplantation, extended criteria donors ECDs have been used 1.

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Liver samples were analyzed using hematoxylin and eosin staining Fig. The flow, pressure, intrahepatic resistance IRand temperature were recorded every 3 h for a total of 6 h during HMP. Representative histological findings and morphometric analysis of pre- and post-HMP samples. Liver histology Liver samples were analyzed using hematoxylin and eosin staining Fig. A; Nanjing Jiancheng Bioengineering Institute according to the manufacturer’s instructions.

The dynamics inflow, pressure and intrahepatic resistance of perfusion were assessed to identify whether this system met the demands for HMP of rat livers. An intravenous injection of 2 ml saline with U heparin Nanjing Jiancheng Bioengineering Institute, Nanjing, China via the right iliac vein was performed for heparinization Fluorescent dyes for cell viability: Nowadays, it has been demonstrated that cold storage, a traditional organ preservation technique, cannot meet the demands of ECD preservation due to the reduced ischemic tolerance of these marginal grafts 78.


However, the limitation of our modification was that this prevention function of Lifeport could no longer be properly initiated.

LifePort kidney transporter: a portable donor kidney transporter/ perfuser

Drawbacks of life improvement none known Research and need The product addresses the serious need for donation organs. When creating this portable device it was vital that the extensive engineering complexities were solved, and it had to be easily transported by a wide variety of hospital personnel and air and other transport personnel.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs Licensewhich permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cold preservation of fatty liver grafts: The LifePort Kidney Transporter preserves and protects a donated kidney during the sometimes long, cold journey from recovery to transplantation. AO and PI staining in the liver. A retrospective review of transplant data indicates that these perfused kidneys function better after transplant than statically stored kidneys.

Fully supporting the organ with arterial flow, pressure, and pulse, Lifeport functions much like a hibernative surrogate body. The increase of perfusion resistance due to the relatively small volume of rat liver and large flow of the LifePort using prime mode typically initiates the prevention function and causes the machine to stop.

One-year results of a prospective, randomized trial comparing two machine perfusion devices used for kidney preservation.

Our Website uses cookies to improve your experience. Results indicated that the levels of endothelin at 0, 3 and kieney h were 0. Abstract The protective mechanisms for liver preservation associated with hypothermic machine perfusion HMP remain unclear.


Received Dec 22; Accepted Jul The isolated perfused rat liver: During HMP, the cells in different areas of the rat liver were stained along with the perfusate distribution viable cells were stained by AO, dead cells were stained by PI as previously described China Find articles by Cheng Zeng.

Functionality and use of design The LifePort kidney Transporter gently perfuses kidneys with cold physiologic solution to improve orden condition during transport to transplant recipient. Hepatic effluent was collected from the catheter cannulated in the suprahepatic vena cava every 3 h of the 6-h HMP period and the levels of alanine transaminase ALT and lactate dehydrogenase LDH were analyzed. Once the abdomen was exposed by performing a midline incision and the liver was freed from the ligamentous attachments, the common bile duct was cannulated using an epidural guiding tube Jiangsu Changfeng Medical Industry Co.

The Lifeport Kidney Transporter

Detection of endothelin was performed to determine the level of shear stress and pressure damage to the endothelial cell layer due to HMP. Continuous HMP via the portal vein for liver preservation is capable of simulating hemodynamics of the portal vein and has been widely applied in a number of previous studies 1221 The final liffport needed to be solved was the measurement of portal inflow. Therefore, to assess the extent of cellular damage, biochemical and histological parameters were investigated to judge the damage profile due to HMP.